Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgfr1tm6Jrt
Name:	fibroblast growth factor receptor 1; targeted mutation 6, Janet Rossant
MGI ID:	MGI:2153351
Synonyms:	Fgfr1n15YF, n15, n15YF
Gene:	Fgfr1  Location: Chr8:26008808-26067819 bp, + strand  Genetic Position: Chr8, 14.12 cM
Alliance:	Fgfr1tm6Jrt page

Germline Transmission:	Earliest citation of germline transmission: J:49154
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A loxP flanked neomycin cassette was inserted into intron 15, and point mutations were introduced into the sequences encoding the one of the autophosphorylation sites and the PLCgamma binding site that altered the corresponding amino acids from tyrosine to phenylalanine. This is a hypomorphic allele. (J:49154)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

17 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr1 Mutation:	221 strains or lines available

Original:	J:49154 Partanen J, et al., Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 1;12(15):2332-44
All:	4 reference(s)