Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabrg2tm2Geh
Name:	gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 2, Gregg E Homanics
MGI ID:	MGI:3579440
Gene:	Gabrg2  Location: Chr11:41801030-41891684 bp, - strand  Genetic Position: Chr11, 24.8 cM
Alliance:	Gabrg2tm2Geh page

Germline Transmission:	Earliest citation of germline transmission: J:98560
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: A targeting vector was constructed to flank exon 8 with loxP sites. A neomycin selection cassette was placed downstream of exon 8, within the floxed sequence. Gene expression was demonstrated to be highly variable, ranging from 10-95% of normal, with the average reduction being 65%. Immunohistochemical analysis demonstrated that protein levels were variably reduced. (J:98560)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabrg2 Mutation:	41 strains or lines available

Original:	J:98560 Chandra D, et al., GABAA receptor gamma2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci. 2005 Apr 25;6(1):30
All:	1 reference(s)