Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm1(OTX1)Asim
Name:	orthodenticle homeobox 2; targeted mutation 1, Antonio Simeone
MGI ID:	MGI:2153202
Synonyms:	hOtx12
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm1(OTX1)Asim page

Germline Transmission:	Earliest citation of germline transmission: J:49817
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A human OTX1 cDNA with an SV40 poly(A) signal was fused to the Otx2 promoter elements, and part of exon 1 and exon 2 were deleted. This allele expresses the human OTX1 protein under Otx2 transcriptional control. (J:49817)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:49817 Acampora D, et al., Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104
All:	2 reference(s)