Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Irf8myls
Name:	interferon regulatory factor 8; myeloproliferative syndrome
MGI ID:	MGI:3578920
Synonyms:	Icsbp1C294, Irf8BXH2, IRF-8C294, Irf8m, Irf8R294C
Gene:	Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Alliance:	Irf8myls page

Strain of Origin:

BXH2/TyJ

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: Sequencing revealed a C-to-T transition at coding nucleotide 880, creating an arginine to cysteine substitution at codon 294 (p.R294C) within the putative IAD domain. (J:97931) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:	32 strains or lines available

Original:	J:88564 Turcotte K, et al., Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004 Mar 15;103(6):2343-50
All:	21 reference(s)