Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Spry2tm1.1Mrt
Name:	sprouty RTK signaling antagonist 2; targeted mutation 1.1, Gail R Martin
MGI ID:	MGI:3578633
Synonyms:	Spry2-, Spry2deltaORF
Gene:	Spry2  Location: Chr14:106129381-106134253 bp, - strand  Genetic Position: Chr14, 56.16 cM
Alliance:	Spry2tm1.1Mrt page

Germline Transmission:	Earliest citation of germline transmission: J:98303
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Crossing Spry2tm1Mrt mice with mice expressing cre recombinase in the germline removed the ORF and created a null allele. (J:98303)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	153 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

List all tumor models in MMHCdb carrying Spry2tm1.1Mrt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry2 Mutation:	24 strains or lines available

Original:	J:98303 Shim K, et al., Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell. 2005 Apr;8(4):553-64
All:	44 reference(s)