Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Vwftm1Wgr Name: Von Willebrand factor; targeted mutation 1, Denisa D Wagner MGI ID: MGI:2153009 Synonyms: vWf-, VWF KO Gene: Vwf  Location: Chr6:125529911-125663642 bp, + strand  Genetic Position: Chr6, 59.32 cM Alliance: Vwftm1Wgr page

Spontaneous bleeding events in Vwftm1Wgr/Vwftm1Wgr mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:49083
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into intron 5. Northern blot analysis revealed that no normal transcripts were present in homozygous mice, and immunofluorescence experiments demonstrated that the protein was not present in blood smears of homozygous mice. (J:49083)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vwf Mutation:	139 strains or lines available

Original:	J:49083 Denis C, et al., A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9524-9
All:	97 reference(s)