Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pcsk9tm1Jdh
Name:	proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Jay D Horton
MGI ID:	MGI:3577021
Synonyms:	Pcsk9-
Gene:	Pcsk9  Location: Chr4:106299531-106321522 bp, - strand  Genetic Position: Chr4, 49.67 cM
Alliance:	Pcsk9tm1Jdh page

Germline Transmission:	Earliest citation of germline transmission: J:97836
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing a neomycin resistance gene was inserted to replace the 3' half of exon 2 through exon 4. Northern blot of mutant livers confirmed absence of transcript. Immunoblot of livers further confirmed absence of protein. (J:97836)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pcsk9 Mutation:	42 strains or lines available

Original:	J:97836 Rashid S, et al., Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5374-9
All:	35 reference(s)