Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Fgfr1Hspy Name: fibroblast growth factor receptor 1; hush puppy MGI ID: MGI:3574787 Synonyms: DEA9 Gene: Fgfr1  Location: Chr8:26008808-26067819 bp, + strand  Genetic Position: Chr8, 14.12 cM Alliance: Fgfr1Hspy page

E8.5 Fgfr1Hspy/Fgfr1Hspy embryos show a restriction at the embryonic/extra-embryonic boundary (arrow) Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

C3HeB/FeJ

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU-mutagenesis induced a T to A transversion in exon 15 that results in the amino acid substitution of arginine for tryptophan at position 691 (W691R). Reduced transcript expression was confirmed by RT-PCR. (J:82809, J:171915) Inheritance:    Not Specified

Identification of the mutation in Fgfr1Hspy

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgfr1 Mutation:	221 strains or lines available

Original:	J:95895 Pau H, et al., Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects. Laryngoscope. 2005 Jan;115(1):116-24
All:	5 reference(s)