Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Akt3tm1Mbb
Name:	thymoma viral proto-oncogene 3; targeted mutation 1, Morris J Birnbaum
MGI ID:	MGI:3574346
Synonyms:	Ak3-, Akt3-
Gene:	Akt3  Location: Chr1:176847639-177085769 bp, - strand  Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
Alliance:	Akt3tm1Mbb page

Germline Transmission:	Earliest citation of germline transmission: J:96823
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence containing nucleotides 209-320 in exon 3 was replaced with a loxP flanked PGK-hygro-pA cassette, resulting in a frame shift in the ORF and a truncation of the resulting protein. Western blot of mutant brain tissue demonstrated that protein was undetectable. (J:96823)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Akt3tm1Mbb

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt3 Mutation:	42 strains or lines available

Original:	J:96823 Easton RM, et al., Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005 Mar;25(5):1869-78
All:	28 reference(s)