Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Dmdtm1.1Khan
Name:	dystrophin, muscular dystrophy; targeted mutation 1.1, Kazunori Hanaoka
MGI ID:	MGI:3531484
Gene:	Dmd  Location: ChrX:81992476-84249747 bp, + strand  Genetic Position: ChrX, 38.38 cM, cytoband C
Alliance:	Dmdtm1.1Khan page

Germline Transmission:	Earliest citation of germline transmission: J:96210
Parent Cell Line:	TT2F (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was produced from Dmdtm1Khan. The entire 2.4 Mb Dmd gene was removed by transient expression of cre recombinase in correctly targeted ES cells. RT-PCR and Western blot analyses failed to detect any expressions of full-length and short isoforms in muscle, cerebrum, and cerebellum. (J:96210)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmd Mutation:	153 strains or lines available

Original:	J:96210 Kudoh H, et al., A new model mouse for Duchenne muscular dystrophy produced by 2.4Mb deletion of dystrophin gene using Cre-loxP recombination system. Biochem Biophys Res Commun. 2005 Mar 11;328(2):507-16
All:	7 reference(s)