Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kdrtm2.1Msh
Name:	kinase insert domain protein receptor; targeted mutation 2.1, Masabumi Shibuya
MGI ID:	MGI:3530469
Synonyms:	Flk-11212F
Gene:	Kdr  Location: Chr5:76093487-76139118 bp, - strand  Genetic Position: Chr5, 40.23 cM
Alliance:	Kdrtm2.1Msh page

Germline Transmission:	Earliest citation of germline transmission: J:96124
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to introduce substitution Y1212F (TAT to TTC) into exon 27. Crossing with mice expressing cre in the germ line deleted a floxed neo from intron 26. Western blot of mutant lung lysates demonstrated protein expression levels were similar to that of wild-type. (J:96124)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:	71 strains or lines available

Original:	J:96124 Sakurai Y, et al., Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
All:	1 reference(s)