Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Msh6tm1Htr
Name:	mutS homolog 6; targeted mutation 1, Hein te Riele
MGI ID:	MGI:2151803
Gene:	Msh6  Location: Chr17:88282490-88298320 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance:	Msh6tm1Htr page

Germline Transmission:	Earliest citation of germline transmission: J:59561
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Part of exon 4 was replaced with a vector containing the puromycin resistance gene. (J:59561)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Msh6tm1Htr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh6 Mutation:	52 strains or lines available

Original:	J:59561 de Wind N, et al., HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet. 1999 Nov;23(3):359-62
All:	6 reference(s)