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Hoxb1tm1Brd
Targeted Allele Detail
Nomenclature
Symbol: Hoxb1tm1Brd
Name: homeobox B1; targeted mutation 1, Allan Bradley
MGI ID: MGI:2151762
Synonyms: Hoxb-1-, Hoxb1null
Gene: Hoxb1  Location: Chr11:96256578-96259082 bp, + strand  Genetic Position: Chr11, 59.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37450
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsInsertion of an in-frame lacZ gene and neomycin cassette into the sequences encoding the first exon. No wild-type protein was detected in E9.5 embryos as assayed by whole mount immunohistochemisty. (J:37450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 68 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb1 Mutation:  18 strains or lines available
References
Original:  J:37450 Studer M, et al., Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature. 1996 Dec 19-26;384(6610):630-4
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory