Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Adcy10tm1Lex
Name:	adenylate cyclase 10; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3529121
Synonyms:	Lex/Sacytm1 KO, sAC-, Sacy-, Sacytm1Jgo, Sacytm1Lex, SacytmLex
Gene:	Adcy10  Location: Chr1:165312752-165404343 bp, + strand  Genetic Position: Chr1, 72.83 cM
Alliance:	Adcy10tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:88649
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-lacZ gene replaced exons 2, 3, and 4. In situ analysis confirmed the absence of endogenous protein in the testis. RT-PCR showed a very low level of transcript expression in the testis that is likely due to read through of the IRES-lacZ cassette. This mutant transcript cannot produce functional protein due to frameshift mutations. (J:88649)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adcy10 Mutation:	83 strains or lines available

Original:	J:88649 Esposito G, et al., Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2993-8
All:	20 reference(s)