Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn11atm1Lex
Name:	sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3528983
Gene:	Scn11a  Location: Chr9:119582829-119654522 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
Alliance:	Scn11atm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:157066
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a IRES-LacZ Neo cassette by homologous recombination. Expression in the brain, dorsal root ganglia and spinal cord was abolished as determined by quantitative RT-PCR.

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn11a Mutation:	86 strains or lines available

Original:	J:157066 Hillsley K, et al., Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice. J Physiol. 2006 Oct 1;576(Pt 1):257-67
All:	2 reference(s)