Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm2Asim
Name:	orthodenticle homeobox 2; targeted mutation 2, Antonio Simeone
MGI ID:	MGI:2150146
Synonyms:	Otx2lambda
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm2Asim page

Germline Transmission:	Earliest citation of germline transmission: J:71034
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The insertion disrupts the 3' UTR of the gene. It introduces a short piece of bacteriophage lambda DNA into the gene as a tag for molecular detection. A neomycin cassette was also inserted 3' to the lambda DNA tag. (J:71034)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:71034 Boyl PP, et al., Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Development. 2001 Aug;128(15):2989-3000
All:	2 reference(s)