Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp1a1tm2Ling
Name:	ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 2, Jerry B Lingrel
MGI ID:	MGI:3527337
Synonyms:	alpha1S
Gene:	Atp1a1  Location: Chr3:101483535-101512000 bp, - strand  Genetic Position: Chr3, 44.3 cM, cytoband F3
Alliance:	Atp1a1tm2Ling page

Germline Transmission:	Earliest citation of germline transmission: J:95157
Parent Cell Line:	Duffy (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted Mutation:    Nucleotide substitutions   Mutation details: Two point mutations were introduced into the first extracellular domain of exon 4: R111Q and D122N. Western blot showed that protein expression was normal. (J:95157)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp1a1 Mutation:	59 strains or lines available

Original:	J:95157 Dostanic I, et al., The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem. 2004 Dec 24;279(52):54053-61
All:	13 reference(s)