Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zap70st
Name:	zeta-chain (TCR) associated protein kinase; strange
MGI ID:	MGI:3526403
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70st page

Strain of Origin:

Not Specified

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: RT-PCR and sequence analysis revealed eight nucleotide differences relative to wild-type sequence. Seven were silent and one, a C-to-T transition, caused an arginine to cystein change at position 464 (p.R464C), thereby disrupting the conserved DLAARN motif within the kinase domain. (J:41170) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:41170 Wiest DL, et al., A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997 Jun;6(6):663-71
All:	2 reference(s)