Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ctnnb1tm3Wbm
Name:	catenin beta 1; targeted mutation 3, Walter Birchmeier
MGI ID:	MGI:2148593
Synonyms:	beta-catlacZ(hygro)
Gene:	Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance:	Ctnnb1tm3Wbm page

Germline Transmission:	Earliest citation of germline transmission: J:60391
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ gene was inserted in-frame into the gene, fused to the endogenous transcription start site. A hygromycin selection cassette followed the lacZ gene. Northern blot analysis on RNA derived from homozygous ES cells demonstrated that no detectable transcript was produced from this allele, and western blot analysis on homozygous ES cells confirmed that no stable protein is produced from this allele (data not shown). (J:60391)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:	49 strains or lines available

Original:	J:60391 Huelsken J, et al., Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
All:	1 reference(s)