Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Car12Tn(sb-T2/GT2/tTA)4563.1Dla
Name:	carbonic anhydrase 12; transposon insertion 4563.1, David A Largaespada
MGI ID:	MGI:3526109
Synonyms:	02A-0001, Car12Tn(sb-T2/GT2/tTA)1.1Dla, Car12Tn(sb-T2/GT2/tTA)2.1Dla
Gene:	Car12  Location: Chr9:66620968-66674127 bp, + strand  Genetic Position: Chr9, 36.09 cM
Alliance:	Car12Tn(sb-T2/GT2/tTA)4563.1Dla page

Strain of Origin:

Not Applicable

Allele Type:    Transposon induced (Inserted expressed sequence) Mutation:    Transposon insertion   Mutation details: This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the first intron of this gene. The Sleeping Beauty transposon construct includes a Carp beta-actin splice acceptor and exon sequences with stop codons in all three reading frames, followed by the EMCV internal ribosome entry site (IRES) and Clontech's Tet-off cDNA, with an SV40 polyadenylation signal, all between the inverted terminal repeats of the transposon (IR/DRs), This mutation was generated by germline mobilization of chromosomally-resident transposons from concatemer line 4563. As a consequence, this particular transposon insertion is not unique in the carrier strain. Multiple other linked insertions may exist with this insertion, although none of the others have been shown to be in genes at the time of submission. (J:117975)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Car12 Mutation:	23 strains or lines available

Original:	J:117975 Geurts AM, et al., Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol. 2006;6:30
All:	1 reference(s)