Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ap3b1tm1.1Sms
Name:	adaptor-related protein complex 3, beta 1 subunit; targeted mutation 1.1, Suzanne L Mansour
MGI ID:	MGI:3525672
Synonyms:	Ap3b1L
Gene:	Ap3b1  Location: Chr13:94495468-94702825 bp, + strand  Genetic Position: Chr13, 49.22 cM
Alliance:	Ap3b1tm1.1Sms page

Germline Transmission:	Earliest citation of germline transmission: J:66256
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An IRES-lacZ and a floxed PGKneomycin selection cassette was inserted into the coding region of the gene. Subsequent transient transcription of Cre recombinase removed the neomycin selection cassette. Northern blot analysis on RNA derived from spleen and kidney of homozygous mice confirmed that no detectable transcript was expressed from this allele. (J:66256)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ap3b1 Mutation:	95 strains or lines available

Original:	J:66256 Yang W, et al., Defective organellar membrane protein trafficking in Ap3b1-deficient cells. J Cell Sci. 2000 Nov;113(Pt 22):4077-86
All:	5 reference(s)