Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	DmdGt(ROSABetageo)1Mpd
Name:	dystrophin, muscular dystrophy; gene trap 1, Karin Wertz
MGI ID:	MGI:2148259
Synonyms:	Dmdmdx-betageo, mdx-betageo
Gene:	Dmd  Location: ChrX:81992476-84249747 bp, + strand  Genetic Position: ChrX, 38.38 cM, cytoband C
Alliance:	DmdGt(ROSABetageo)1Mpd page

Germline Transmission:	Earliest citation of germline transmission: J:47968
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: Insertion of a gene trap vector resulted in aberrant splicing from exon 63 to the inserted Beta-geo gene. RT-PCR analysis demonstrated that the mRNA was mutated in this allele, although a very low level of wild-type transcript was detected in brain. Full length wild-type protein could not be detected by Western blotting in tissue extracts derived from hemizygous males. (J:47968)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmd Mutation:	153 strains or lines available

Original:	J:47968 Wertz K, et al., Dmd(mdx-beta geo): a new allele for the mouse dystrophin gene. Dev Dyn. 1998 Jun;212(2):229-41
All:	12 reference(s)