Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Cxcr4tm2Yzo
Name:	C-X-C motif chemokine receptor 4; targeted mutation 2, Yong-Rui Zou
MGI ID:	MGI:3525214
Synonyms:	Cxcr4f, Cxcr4loxP
Gene:	Cxcr4  Location: Chr1:128515936-128520030 bp, - strand  Genetic Position: Chr1, 56.43 cM
Alliance:	Cxcr4tm2Yzo page

Germline Transmission:	Earliest citation of germline transmission: J:94911
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 1 and a third loxP site was introduced into exon 2. Crossing with EIIa-cre mice resulted in the excision of the neo, leaving exon 2 flanked with loxP sites. (J:94911)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Cxcr4tm2Yzo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:	40 strains or lines available

Original:	J:94911 Nie Y, et al., The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 2004 Nov 1;200(9):1145-56
All:	89 reference(s)