Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-1tm1Rdl
Name:	NK2 homeobox 1; targeted mutation 1, Roberto Di Lauro
MGI ID:	MGI:3525207
Synonyms:	Titf1Foxe1
Gene:	Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance:	Nkx2-1tm1Rdl page

Germline Transmission:	Earliest citation of germline transmission: J:95017
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A sequence from rat Foxe1 replaced the endogenous sequence spanning from the start site to the end of the homeobox (nucleotide positions 7957 to 9480). Sv40 pA was added after the stop codon, as well as a PGK-neo cassette. The inserted sequence was ectopically expressed in Titf1 expression domains like the lung and diencephalons, (J:95017)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

5 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:	24 strains or lines available

Original:	J:95017 Parlato R, et al., An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol. 2004 Dec 15;276(2):464-75
All:	2 reference(s)