Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Mapttm1Noh
Name:	microtubule-associated protein tau; targeted mutation 1, Nobutaka Hirokawa
MGI ID:	MGI:2138030
Synonyms:	tau-
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm1Noh page

Germline Transmission:	Earliest citation of germline transmission: J:19030
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neomycin cassette was inserted into exon 1 of the gene. Mapt protein was not detected by Western blot using anti-Mapt antibodies in crude extracts from cerebrum and cerebellum or the dorsal root ganglia of homozygous mutant mice. (J:19030)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:19030 Harada A, et al., Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 1994 Jun 9;369(6480):488-91
All:	6 reference(s)