Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptger1tm1Sna
Name:	prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Shuh Narumiya
MGI ID:	MGI:2137762
Synonyms:	EP1-, Ptger1-
Gene:	Ptger1  Location: Chr8:84393307-84399382 bp, + strand  Genetic Position: Chr8, 40.22 cM
Alliance:	Ptger1tm1Sna page

Germline Transmission:	Earliest citation of germline transmission: J:70534
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette into the FspI site of exon 2, located immediately before the sequence encoding the first transmembrane domain. Northern blots of renal tissue did not detect Ptger1 transcript in homozygous mutant mice. (J:70534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptger1tm1Sna

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptger1 Mutation:	22 strains or lines available

Original:	J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:	45 reference(s)