Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gucy2dtm1Sdm
Name:	guanylate cyclase 2d; targeted mutation 1, Steven D Munger
MGI ID:	MGI:3521821
Synonyms:	Gucy2d-
Gene:	Gucy2d  Location: Chr7:98089623-98126685 bp, + strand  Genetic Position: Chr7, 53.86 cM
Alliance:	Gucy2dtm1Sdm page

Germline Transmission:	Earliest citation of germline transmission: J:124965
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An IRES-Mapt-lacZ reporter with a floxed neo cassette was inserted between exon 2 and 3. RT-PCR confirmed the lack of transcription from the null allele. LacZ expression was confirmed by immunohistochemistry in a small number of main olfactory epithelium consistent with the small number of Gucy2d+ neurons previously reported. Cre-mediated recombination removed the floxed neo cassette. (J:124965)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy2d Mutation:	42 strains or lines available

Original:	J:124965 Leinders-Zufall T, et al., Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14507-12
All:	5 reference(s)