Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il10tm1.1Roer
Name:	interleukin 10; targeted mutation 1.1, Axel Roers
MGI ID:	MGI:3521569
Synonyms:	IL-10D
Gene:	Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM
Alliance:	Il10tm1.1Roer page

Germline Transmission:	Earliest citation of germline transmission: J:94537
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion     Crossing Il10tm1Roer with Cre deleter mice resulted in the excision of exon 1. (J:94537)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:	44 strains or lines available

Original:	J:94537 Roers A, et al., T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med. 2004 Nov 15;200(10):1289-97
All:	6 reference(s)