Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rettm2Cos
Name:	ret proto-oncogene; targeted mutation 2, Frank Costantini
MGI ID:	MGI:2136895
Synonyms:	retMEN2B-neo
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm2Cos page

Germline Transmission:	Earliest citation of germline transmission: J:60659
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Single point mutation   Mutation details: A T to C transition in codon 919, the equivalent codon to human 918, resulted in a protein which encoded threonine instead of methionine at this position (M919T). Silent mutations in codons 920 and 921 abolished a MunI endonuclease site. A loxP flanked neomycin cassette was inserted into an adjacent intron. (J:60659)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:60659 Smith-Hicks CL, et al., C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. EMBO J. 2000 Feb 15;19(4):612-22
All:	1 reference(s)