Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabbr1tm2.1Bet
Name:	gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 2.1, Bernhard Bettler
MGI ID:	MGI:3512743
Synonyms:	GABAB(1)-
Gene:	Gabbr1  Location: Chr17:37356888-37385197 bp, + strand  Genetic Position: Chr17, 19.16 cM
Alliance:	Gabbr1tm2.1Bet page

Germline Transmission:	Earliest citation of germline transmission: J:94234
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Crossing Gabbr1tm2Bet with Cre-deleter mice resulted in this allele in which exons 7 and 8 are replaced with a single lox511 site. This region is involved in GABA-binding and the removal of the exons caused a frame shift that prevented translation of the full-length protein. Immunoblot indicated the lack of protein in brain extracts from mutants. (J:94234)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabbr1 Mutation:	71 strains or lines available

Original:	J:94234 Haller C, et al., Floxed allele for conditional inactivation of the GABA(B(1)) gene. Genesis. 2004 Nov;40(3):125-30
All:	2 reference(s)