Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Akt1/EGFP)Glas
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David J Glass
MGI ID:	MGI:3512295
Synonyms:	AktInd.Tg, c.a.Akt-EGFP
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Akt1/EGFP)Glas page

Germline Transmission:	Earliest citation of germline transmission: J:94134
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1(Akt1/EGFP)Glas expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Akt1 (MGI:87986)   Mutation details: The HSA-driven CreERt2 transgene was inserted in cis with a cassette containing a constitutively active form of Atk1 fused to EGFP (c.a.Akt-EGFP). Prior to the addition of tamoxifen, the HSA promoter drives transctiption of CreERt2, with absence of c.a.Akt-EGFP transcription. Upon the addition of tamoxifen, CreERt2 expression would drive its own excision, leaving the c.a.Akt-EGFP cassette downstream of the HSA promoter. (J:94134)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:94134 Lai KM, et al., Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol. 2004 Nov;24(21):9295-304
All:	1 reference(s)