Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sh2d1atm1Vei
Name:	SH2 domain containing 1A; targeted mutation 1, Andre Veillette
MGI ID:	MGI:3512182
Synonyms:	sapR78A
Gene:	Sh2d1a  Location: ChrX:41591442-41610974 bp, + strand  Genetic Position: ChrX, 23.2 cM, cytoband A5
Alliance:	Sh2d1atm1Vei page

Germline Transmission:	Earliest citation of germline transmission: J:93886
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Using a knock-in strategy, arginine 78 in exon 3 was replaced by an alanine. Crossing with EIIa-Cre mice removed a floxed neo. The mutation had no effect on protein abundance. (J:93886)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1a Mutation:	10 strains or lines available

Original:	J:93886 Davidson D, et al., Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity. 2004 Nov;21(5):707-17
All:	6 reference(s)