Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Vegfatm2Pec
Name:	vascular endothelial growth factor A; targeted mutation 2, Peter Carmeliet
MGI ID:	MGI:2136623
Synonyms:	Vegfdelta
Gene:	Vegfa  Location: Chr17:46327919-46343295 bp, - strand  Genetic Position: Chr17, 22.79 cM
Alliance:	Vegfatm2Pec page

Germline Transmission:	Earliest citation of germline transmission: J:69797
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Deletion of the hypoxia-response element (HRE) in the promoter of the gene. An adajcent neomycin cassette was removed prior to blastocyst injection via Cre-mediated recombination in ES cells, resulting in the final allele. (J:69797)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:	37 strains or lines available

Original:	J:69797 Oosthuyse B, et al., Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001 Jun;28(2):131-8
All:	10 reference(s)