Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfrbtm1Rheu
Name:	platelet derived growth factor receptor, beta polypeptide; targeted mutation 1, Rainer Heuchel
MGI ID:	MGI:3511432
Synonyms:	D849N
Gene:	Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Pdgfrbtm1Rheu page

Germline Transmission:	Earliest citation of germline transmission: J:93973
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Humanized sequence) Mutation:    Single point mutation   Mutation details: A G to A transition resulting in an amino acid change of D849N was introduced in exon 17 via homologous recombination. A loxP-flanked PGK-neo expression cassette was also inserted in intron 15. (J:93973)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:	84 strains or lines available

Original:	J:93973 Chiara F, et al., A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. J Biol Chem. 2004 Oct 8;279(41):42516-27
All:	3 reference(s)