Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Leprtm1.2Chua Name: leptin receptor; targeted mutation 1.2, Streamson C Chua, Jr MGI ID: MGI:3511285 Synonyms: Leprdelta, Leprdelta17 Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM Alliance: Leprtm1.2Chua page

Obesity in Leprtm1.2Chua/Leprtm1.2Chua mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:94019
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Leprtm1.1Chua mice crossed with Cre transgenic mice created this allele in which exon 17 is excised. The predicted result is a truncated receptor protein for all isoforms, with a frameshift in the 3' end of exon 16, thus causing a Lepr-B terminal exon consisting of 14 amino acids and a premature stop codon. RT-PCR confirmed the deletion. (J:94019)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Original:	J:94019 McMinn JE, et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85
All:	7 reference(s)