Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Rxratm2Ipc
Name:	retinoid X receptor alpha; targeted mutation 2, Pierre Chambon
MGI ID:	MGI:2136274
Synonyms:	RXR-alpha-
Gene:	Rxra  Location: Chr2:27566452-27652969 bp, + strand  Genetic Position: Chr2, 19.38 cM
Alliance:	Rxratm2Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:20550
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of exon 4 with a PGK-Neo cassette. Western analysis using a polyclonal antibody directed against the N-terminus failed to detect the protein in homozygous mutant animals. (J:20550)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:	30 strains or lines available

Original:	J:20550 Kastner P, et al., Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 1994 Sep 23;78(6):987-1003
All:	16 reference(s)