Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pitx2tm2Jfm
Name:	paired-like homeodomain transcription factor 2; targeted mutation 2, James F Martin
MGI ID:	MGI:2136269
Synonyms:	delta abhypoc, Pitx2PZNeo
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm2Jfm page

Germline Transmission:	Earliest citation of germline transmission: J:69854
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Hypomorph, Modified isoform(s), Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-lacZ cassette followed by a loxP-flanked neomycin resistance cassette replaced a genomic fragment containing the coding region of exon 2 and all of exon 3. This allele encodes the heart- and lung-specific c isoform in the absence of the a and b isoforms. The presence of the retained neomycin resistance cassette results in a hypomorphic allele. (J:69854)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	38 strains or lines available

Original:	J:69854 Liu C, et al., Regulation of left-right asymmetry by thresholds of Pitx2c activity. Development. 2001 Jun;128(11):2039-48
All:	4 reference(s)