Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Fgfr3tm2Wei Name: fibroblast growth factor receptor 3; targeted mutation 2, Weizmann Institute of Science MGI ID: MGI:2135636 Synonyms: Fgfr3G374R, FGFR3G374Rneo- Gene: Fgfr3  Location: Chr5:33879068-33894412 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B Alliance: Fgfr3tm2Wei page

Anatomical defects of the Fgfr3tm2Wei/Fgfr3+ mouse Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:54829
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Single point mutation   Mutation details: Introduction of a G to A point mutation in codon 374 (orthologous to human codon 380) that altered the corresponding amino acid from a glycine to an arginine. A loxP flanked neomycin cassette inserted into intron 4 was removed by cre-mediated recombination. Northern blot analysis revealed that a normal molecular weight mRNA was made in homozygous mutants. (J:54829)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:	52 strains or lines available

Original:	J:54829 Wang Y, et al., A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4455-60
All:	3 reference(s)