Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Rettm2(RET)Jmi
Name:	ret proto-oncogene; targeted mutation 2, Jeffrey Milbrandt
MGI ID:	MGI:3057332
Synonyms:	Ret9, RetRET9
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm2(RET)Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:93262
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Rettm2(RET)Jmi expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human RET (5979) Ret  (MGI:97902)   Mutation details: Human RET9 cDNA and a floxed neo were inserted into exon 1 of the endogenous locus. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain. (J:93262)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:93262 Jain S, et al., Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development. 2004 Dec;131(21):5503-13
All:	9 reference(s)