Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fn1tm1Ksek
Name:	fibronectin 1; targeted mutation 1, Kiyotoshi Sekiguchi
MGI ID:	MGI:3056581
Synonyms:	EDB-, EIIIB-null
Gene:	Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance:	Fn1tm1Ksek page

Germline Transmission:	Earliest citation of germline transmission: J:93250
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon EDB (EIIIB) was deleted upon transient expression of Cre recombinase, which excised the floxed sequence containing a neomycin resistance gene and the exon. Immunoblot of mutant MEFs against an anti-EDB antibody indicated lack of protein from this exon. (J:93250)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:	129 strains or lines available

Original:	J:93250 Fukuda T, et al., Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res. 2002 Nov 1;62(19):5603-10
All:	3 reference(s)