Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfrbtm2Sor
Name:	platelet derived growth factor receptor, beta polypeptide; targeted mutation 2, Philippe Soriano
MGI ID:	MGI:2135519
Gene:	Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Pdgfrbtm2Sor page

Germline Transmission:	Earliest citation of germline transmission: J:20016
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A promoterless beta-galactosidase/neomycin gene fusion (beta-geo) was inserted in frame into the exon coding for the signal peptide. Southern blot analysis demonstrated that three tandem copies of the beta-geo gene were present in a concatamer. Northern blot analysis failed to detect a PDGFbetaR transcript in homozygous mutants. Western blot analysis of total protein failed to detect any immunoreactive PDGFbetaR in homozygous mutants. (J:20016)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:	84 strains or lines available

Original:	J:20016 Soriano P, Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994 Aug 15;8(16):1888-96
All:	1 reference(s)