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Traf3tm1Bal
Targeted Allele Detail
Nomenclature
Symbol: Traf3tm1Bal
Name: TNF receptor-associated factor 3; targeted mutation 1, David Baltimore
MGI ID: MGI:2135257
Synonyms: TRAF3-
Gene: Traf3  Location: Chr12:111166370-111267153 bp, + strand  Genetic Position: Chr12, 60.94 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37065
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the first two exons. Western blot analysis using a polyclonal antibody against the C-terminal portion did not detect protein in three tissues of homozygous mutant mice. Northern blot analysis using a cDNA fragment that encodes the C-terminus did not detect mRNA in brain of homozygous mutant mice. (J:37065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3 Mutation:  30 strains or lines available
References
Original:  J:37065 Xu Y, et al., Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity. 1996 Nov;5(5):407-15
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory