Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Traf3tm1Bal
Name:	TNF receptor-associated factor 3; targeted mutation 1, David Baltimore
MGI ID:	MGI:2135257
Synonyms:	TRAF3-
Gene:	Traf3  Location: Chr12:111132804-111233587 bp, + strand  Genetic Position: Chr12, 60.94 cM, cytoband F
Alliance:	Traf3tm1Bal page

Germline Transmission:	Earliest citation of germline transmission: J:37065
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced the first two exons. Western blot analysis using a polyclonal antibody against the C-terminal portion did not detect protein in three tissues of homozygous mutant mice. Northern blot analysis using a cDNA fragment that encodes the C-terminus did not detect mRNA in brain of homozygous mutant mice. (J:37065)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3 Mutation:	42 strains or lines available

Original:	J:37065 Xu Y, et al., Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity. 1996 Nov;5(5):407-15
All:	9 reference(s)