Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargtm1Uls
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1, Beatrice Desvergne
MGI ID:	MGI:3055128
Synonyms:	PPARG-
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1Uls page

Germline Transmission:	Earliest citation of germline transmission: J:92826
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, containing the translational start site of the Pparg1 isoform, and part of exon 2, encoding the first zinc finger of the DNA binding domain, were replaced with a PGK-neo cassette. Both isoform 1 and 2 were disrupted by this event, as shown by lack of protein in Western blot of white adipose tissue. (J:92826)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	39 strains or lines available

Original:	J:92826 Rieusset J, et al., Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol. 2004 Oct;18(10):2363-77
All:	7 reference(s)