Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lamc1tm1Edg
Name:	laminin, gamma 1; targeted mutation 1, David Edgar
MGI ID:	MGI:1934900
Gene:	Lamc1  Location: Chr1:153094668-153208532 bp, - strand  Genetic Position: Chr1, 65.3 cM
Alliance:	Lamc1tm1Edg page

Germline Transmission:	Earliest citation of germline transmission: J:52418
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An IRES-betageo gene was inserted into exon 1. Northern blot analysis on doubly targeted ES cells demonstrated that no transcript was expressed from this allele. (J:52418)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamc1 Mutation:	143 strains or lines available

Original:	J:52418 Smyth N, et al., Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol. 1999 Jan 11;144(1):151-60
All:	2 reference(s)