Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Trex1tm1Tld
Name:	three prime repair exonuclease 1; targeted mutation 1, Tomas Lindahl
MGI ID:	MGI:3052754
Synonyms:	Trex1-
Gene:	Trex1  Location: Chr9:108887000-108888791 bp, - strand  Genetic Position: Chr9, 59.63 cM
Alliance:	Trex1tm1Tld page

Germline Transmission:	Earliest citation of germline transmission: J:92264
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene cassette replaced sequence encoding amino acids 103-207 of the encoded peptide, including conserved exonuclease magnesium binding motifs II and III. RT-PCR showed no transcript present in mutant spleens. Mutant livers did not demonstrate protein in Western blot analysis. (J:92264)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

List all tumor models in MMHCdb carrying Trex1tm1Tld

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trex1 Mutation:	22 strains or lines available

Original:	J:92264 Morita M, et al., Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 2004 Aug;24(15):6719-27
All:	31 reference(s)