Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax6tm1Pgr
Name:	paired box 6; targeted mutation 1, Peter Gruss
MGI ID:	MGI:1934347
Synonyms:	Pax6lacZ, Pax6-lacZ, Pax6::lacZ
Gene:	Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance:	Pax6tm1Pgr page

Germline Transmission:	Earliest citation of germline transmission: J:40439
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The start codon in exon 4 and the entire paired domain of Pax6 was replaced with a beta-galactosidase gene followed by a neomycin cassette. Beta-galactosidase was expressed in embryos in a pattern identical to Pax6. (J:40439)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	126 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:	90 strains or lines available

Original:	J:40439 St-Onge L, et al., Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature. 1997 May 22;387(6631):406-9
All:	43 reference(s)