Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grap2tm1Eac
Name:	GRB2-related adaptor protein 2; targeted mutation 1, Edward A Clark
MGI ID:	MGI:3051853
Synonyms:	Gads-
Gene:	Grap2  Location: Chr15:80456798-80537055 bp, + strand  Genetic Position: Chr15, 37.88 cM, cytoband E2
Alliance:	Grap2tm1Eac page

Germline Transmission:	Earliest citation of germline transmission: J:92023
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-3, encompassing the majority of the transcript including the ATG, were replaced with a neomycin resistance gene via homologous recombination. Southern blot confirmed recombination. Intracellular staining of thymocytes confirmed lack of protein in mutants. (J:92023)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grap2 Mutation:	23 strains or lines available

Original:	J:92023 Yankee TM, et al., The Gads (GrpL) adaptor protein regulates T cell homeostasis. J Immunol. 2004 Aug 1;173(3):1711-20
All:	5 reference(s)