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Hoxb8tm1.1Jdes
Targeted Allele Detail
Nomenclature
Symbol: Hoxb8tm1.1Jdes
Name: homeobox B8; targeted mutation 1.1, Jacqueline Deschamps
MGI ID: MGI:1934178
Synonyms: Hoxb8lacZneo-
Gene: Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58621
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThis allele is a derivative of Hox8btm1Jdes in which a Cre-mediated recombination event in the germline excised a floxed neomycin/thymidine kinase cassette that had been inserted downstream of a beta-galactosidase gene in the first exon. (J:58621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 51 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:  4 strains or lines available
References
Original:  J:58621 van den Akker E, et al., Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech Dev. 1999 Dec;89(1-2):103-14
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory