Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Per2tm1Brd
Name:	period circadian clock 2; targeted mutation 1, Allan Bradley
MGI ID:	MGI:1934020
Synonyms:	mPer2Brdm1, mPer2m, Per2Brdm1
Gene:	Per2  Location: Chr1:91343704-91387046 bp, - strand  Genetic Position: Chr1, 46.13 cM, cytoband C5
Alliance:	Per2tm1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:56167
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Two exons containing the most conserved region of the gene were replaced with PGK-neo cassette, resulting in the deletion of the PAC subdomain and half of the PAS B domain. RT-PCR and sequence analysis of mutant animals detected a mutant transcript with a predicted protein containing an 87 amino acid deletion. (J:56167)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Per2tm1Brd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Per2 Mutation:	71 strains or lines available

Original:	J:56167 Zheng B, et al., The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature. 1999 Jul 8;400(6740):169-73
All:	98 reference(s)