Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Il4tm1Gru
Name:	interleukin 4; targeted mutation 1, Michael Grusby
MGI ID:	MGI:1934015
Synonyms:	mIL-4
Gene:	Il4  Location: Chr11:53503287-53509492 bp, - strand  Genetic Position: Chr11, 31.97 cM
Alliance:	Il4tm1Gru page

Germline Transmission:	Earliest citation of germline transmission: J:53107
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A modified version of exon 4 of the gene was inserted between the last codon and the translational stop site of the gene. This modified version of exon 4 contained a transmembrane anchor. In addition, a neomycin resistance cassette was inserted 150 nucleotides downstream of the polyadenylation signal of the gene. These modifications allowed production of mice that express a membrane-bound form of the protein. (J:53107)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:	42 strains or lines available

Original:	J:53107 Ho IC, et al., Marking IL-4-producing cells by knock-in of the IL-4 gene. Int Immunol. 1999 Feb;11(2):243-7
All:	1 reference(s)